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GPR45 Rabbit pAb (bs-13538R)  
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產(chǎn)品編號(hào) bs-13538R
英文名稱(chēng) GPR45 Rabbit pAb
中文名稱(chēng) G蛋白偶聯(lián)受體45抗體
別    名 GPCR GPR45; G protein coupled receptor 45; High affinity lysophosphatidic acid receptor; Probable G protein coupled receptor 45; GPCR 45; PSP24 1; PSP24 alpha; PSP24; PSP24(ALPHA); PSP241; PSP24A.  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Human
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPR45: 251-350/372 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR45, also known as PSP24-1 or PSP24-α, is a 372 amino acid orphan receptor that is suspected to play a role in brain function. Expressed in brain, GPR45 has been detected in the basal forebrain, frontal cortex and caudate, but not in thalamus, hippocampus or putamen.

Function:
GPCR GPR54 is a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. GPR45 is an orphan receptor, which may play a role in brain function.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q9Y5Y3

Gene ID:
11250

Database links:

Entrez Gene: 11250 Human

Omim: 604838 Human

SwissProt: Q9Y5Y3 Human



產(chǎn)品圖片
Sample: U251 Cell (Human) Lysate at 40 ug U87mg Cell (human) Lysate at 40 ug Primary: Anti- GPR45 (bs-13538R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42kD Observed band size: 42 kD
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