| 產(chǎn)品編號(hào) |
bs-0250R-BF350 |
| 英文名稱 |
Rabbit Anti-PPAR delta + beta/BF350 Conjugated antibody
|
| 中文名稱 |
BF350標(biāo)記的D型-過(guò)氧化酶活化增生受體抗體 |
| 別 名 |
PPAR delta+beta; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
心血管 免疫學(xué) 細(xì)胞膜受體 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類(lèi)型 |
Polyclonal |
| 交叉反應(yīng) |
Human,
(predicted: Mouse, Rat, )
|
| 產(chǎn)品應(yīng)用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
48kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from mouse PPAR-delta |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 |
Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 產(chǎn)品介紹 |
background:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain.
Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous with maximal levels in placenta and skeletal muscle.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:
Entrez Gene: 5467 Human
Entrez Gene: 19015 Mouse
Entrez Gene: 25682 Rat
Omim: 600409 Human
SwissProt: Q03181 Human
SwissProt: P35396 Mouse
Unigene: 696032 Human
Unigene: 328914 Mouse
Unigene: 96181 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
類(lèi)固醇受體（Steroid Receptors）
研究人員指出該分子的功能，極可能就是阻斷心血管免疫發(fā)炎反應(yīng)的訊號(hào)傳遞過(guò)程。PPAR－delta基因是控制肌肉發(fā)展的重要基因，在增加老鼠耐力的同時(shí)還能幫助它燃燒掉脂肪，研究人員發(fā)現(xiàn)，對(duì)于與新陳代謝有關(guān)的各項(xiàng)疾病，從心臟病到肥胖癥都有啟發(fā)性的意義，他可以阻止脂肪沉淀在動(dòng)脈壁上，進(jìn)而防止動(dòng)脈硬化癥的發(fā)生,該蛋白參與脂肪代謝、肥胖、糖尿病、動(dòng)脈硬化和癌癥的發(fā)病。
在動(dòng)脈硬化現(xiàn)象發(fā)生的早期，免疫細(xì)胞會(huì)促使血管慢性的發(fā)炎，因而造成血管不斷地吸收和輸送脂肪，進(jìn)而導(dǎo)致脂肪的堆積與血管硬化，而PPAR-delta就像警衛(wèi)分子一樣，時(shí)時(shí)降低發(fā)炎反應(yīng)和抑制動(dòng)脈硬化斑的形成，因此該分子應(yīng)該是相關(guān)藥物研發(fā)，相當(dāng)值得切入的目標(biāo)。
研究人員認(rèn)為，這個(gè)發(fā)現(xiàn)將給藥廠研發(fā)治療心血管疾病的新藥提供新的線索。
|
|
|