| 產(chǎn)品編號 |
bs-18088R-PE-Cy7 |
| 英文名稱 |
Rabbit Anti-HSPC142/PE-Cy7 Conjugated antibody
|
| 中文名稱 |
PE-Cy7標(biāo)記的乳腺癌易感基因復(fù)合物HSPC142抗體 |
| 別 名 |
BABA1_HUMAN;
babam1;
BRCA1 A complex subunit MERIT40;
BRISC and BRCA1-A complex member 1;
C19orf62;
FLJ20571;
HSPC142;
hypothetical protein LOC29086;
Mediator of Rap80 interactions and targeting 40 kDa;
Mediator of RAP80 interactions and targeting subunit of 40 kDa;
MERIT 40;
MERIT40;
NBA1;
New component of the BRCA1 A complex;
New component of the BRCA1-A complex;
Uncharacterized protein C19orf62. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 糖尿病 表觀遺傳學(xué) |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Cat, Chinese Hamster, Orangutan, Elephant)
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
36kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human HSPC142 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 產(chǎn)品介紹 |
background:
Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf62 gene product has been provisionally designated C19orf62 pending further characterization.
Function:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
Subcellular Location:
Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks.
Similarity:
Belongs to the BABAM1 family.
Database links:
Entrez Gene: 29086 Human
Entrez Gene: 68251 Mouse
Entrez Gene: 290631 Rat
Omim: 612766 Human
SwissProt: Q9NWV8 Human
SwissProt: Q3UI43 Mouse
SwissProt: Q5XIJ6 Rat
Unigene: 190722 Human
Unigene: 21749 Mouse
Unigene: 74107 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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